Background: The management plan for metastasis to the thyroid from distant primary malignancies remains unclear. Methods: This systematic review is being conducted to evaluate the outcomes for performing thyroidectomy in non thyroidal metastatic cancer. Data: Data was collected via literature search using pubmed, cochrane, web of science, and google scholar.
PICO: Population: Patients undergoing thyroidectomy in nonthyroidal metastatic from distal primary cancer Intervention: Thyroidectomy (lobar/total) Comparison: No comparison group Outcomes: Overall survival Locoregional Recurrence Mortality
Results: As per literature review, renal cell carcinoma was most common, (around 30-35%) patients, followed by lung and gastrointestinal malignancies. Surgical management was associated with improved survival duration (P
Conclusion: Surgical intervention is associated with improved survival, but expected morbidity of untreated tumors is difficult to assess. Site of origin, time to diagnosis, and surgical approach are related to survival and recurrence rates.