Surgical Management of Necrotic Wounds Following Rituximab Therapyfor Waldenstrom’s Macroglobulinemia: A Case Report

Division

North Florida

Hospital

Ocala Regional Medical Center

Document Type

Case Report

Publication Date

12-21-2020

Keywords

Waldenstrom’s Macroglobulinemia, Non Hodgkin Lymphoma, Pediatric Ovarian Cancer, Skin Necrosis, Calciphylaxis, Monoclonal Antibody Therapy

Disciplines

Internal Medicine | Neoplasms | Oncology | Skin and Connective Tissue Diseases

Abstract

We report the case of a 77-year-old woman who developed extensive necrosis of the skin and subcutaneous tissue of bilateral lower extremities following administration of Rituximab antibody therapy for Waldenstrom’s macroglobulinemia. The morphology and presentation of these lesions may represent calciphylaxis, a rare life- threatening disease characterized by soft tissue necrosis. We wish to inform the medical community of the potential for developing this rare condition in patients, especially those with concomitant risk factors, undergoing antibody therapy interventions.

Publisher or Conference

Journal of Case Reports in Cancer

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