The Importance of Early Source Control in Persistent MRSA Bacteremia: A Case Report

Division

Central and West Texas

Hospital

Las Palmas Medical Center

Document Type

Case Report

Publication Date

6-18-2025

Keywords

MRSA, persistent bacteremia, systemic infection, technetium-99

Disciplines

Bacterial Infections and Mycoses | Internal Medicine | Medicine and Health Sciences

Abstract

BACKGROUND: Persistent bacteremia, despite the susceptibility of the causative organism to appropriate antimicrobial therapy, presents a major clinical challenge. In such cases, early identifica-tion and control of the infectious source are essential to prevent complications and reduce mortality.

CASE PRESENTATION: We report the case of a 59-year-old woman with persistent Methicillin-resistant Staphylococcus Aureus (MRSA) bacteremia following spinal surgery. Despite multiple days of in-travenous antibiotic therapy, her blood cultures remained positive for MRSA. A tagged white blood cell (Technetium-99) scan revealed an abscess in the right sacroiliac joint. Surgical drainage of the abscess led to clinical improvement and resolution of bacteremia. Interestingly, cultures of the ab-scess fluid grew Enterococcus faecalis rather than MRSA.

DISCUSSION: This case underscores the importance of early source control in the management of per-sistent bacteremia. Even when the pathogen isolated from the presumed source differs from that in the bloodstream, drainage can play a critical role in resolving systemic infection.

CONCLUSION: Early source control should be pursued in persistent bacteremia, regardless of initial culture results. Imaging studies may assist in locating occult sources, and successful drainage may contribute to clinical improvement even when the primary bloodstream pathogen is not isolated from the source.

Publisher or Conference

Infectious Disorders - Drug Targets

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