Hydralazine Induced ANCA Vasculitis

Authors

Justin Huang, HCA HealthcareFollow
Yasasvi Sabbineni, HCA HealthcareFollow
Sumanth Reddy, HCA HealthcareFollow
Hani Khair, HCA HealthcareFollow

Files

Division

North Texas

Hospital

Medical City Arlington

Specialty

Internal Medicine

Document Type

Poster

Publication Date

2025

Keywords

anti-neutrophil cytoplasmic antibody-associated vasculitis, ANCA Vasculitis, autoimmune diseases

Disciplines

Immune System Diseases | Internal Medicine | Medicine and Health Sciences

Abstract

Hydralazine is a vasodilator commonly used for hypertension. Hydrazine is commonly used in patients who can not tolerate ACEs and ARBs, resistant hypertension, and during pregnancy. Hydralazine has also been implicated in ANCA-associated vasculitis and drug-induced lupus erythematosus. Vasculitis is the presence of inflammatory leukocytes in vessel walls, inflammation can cause loss of vessel integrity which can lead to bleeding and downstream tissue ischemia and necrosis. Antineutrophil cytoplasmic antibody (AΝCΑ)-associated vаsсulitiѕ (ΑΑV) is a necrotizing vаsсսlitis that does not substantially involve the deposition of immune complexes. AΑV predominantly affects small vessels and is associated with ANСΑ specific for myeloperoxidase (MPO-ΑNCΑ) or proteinase 3 (PR3-ΑNСA). Drugs that are commonly associated are propylthiouracil, methimazole thiamazole, carbimazole, hydralazine, and minocycline. Hydralazine is the most common cause. Early detection is vital as cessation of offending medication leads to the resolution of disease progression.

Original Publisher

HCA Healthcare Graduate Medical Education

Recommended Citation

Huang, Justin; Sabbineni, Yasasvi; Reddy, Sumanth; and Khair, Hani, "Hydralazine Induced ANCA Vasculitis" (2025). North Texas Research Forum 2025. 27.
https://scholarlycommons.hcahealthcare.com/northtexas2025/27