North Texas Research Forum 2025
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Division
North Texas
Hospital
Medical City Denton
Specialty
Orthopedic Surgery
Document Type
Poster
Publication Date
2025
Keywords
hip hemiarthroplasty, femoral neck fracture, GLP-1RA, type 2 diabetes
Disciplines
Medicine and Health Sciences | Nutritional and Metabolic Diseases | Orthopedics | Wounds and Injuries
Abstract
Introduction: To determine if the use of glucagon-like peptide-1 receptor agonists (GLP-1RA) in type 2 diabetic mellitus (T2DM) patients affects outcomes after hemiarthroplasty for femoral neck fractures (FNFs). Methods: A retrospective cross-sectional analysis of a local hospital system database was performed using Current Procedural Terminology (CPT) and International Classification of Diseases (ICD-10) codes to identify T2DM patients who were at least 18 years of age who underwent hemiarthroplasty (HA) for FNFs and were on a GLP-1RA at the time of injury. A random patient sample of those who underwent HA and were not on a GLP-1RA was used as a control. Sex, age, body mass index (BMI), smoking status, and Elixhauser comorbidity index (ECI) were control variables. The primary outcomes were initial hospital length of stay (LOS), surgical site infection (SSI) within 90 and 365 days, and medical complications in 30 days. Secondary outcomes were all-cause readmissions within 90 days, implant complications, revision surgery, and in-hospital mortality or discharge to hospice within 365 days. A sub-analysis was performed on patients taking semaglutide, dulaglutide, or liraglutide to those not on GLP-1RA. Results: 499 patients were identified that met study criteria, GLP-1RA use was not significantly associated with an increased risk of medical complication, re-admission within 30 days, hardware failure within 1 year, the likelihood of revision surgery within 1 year, in-hospital mortality/discharge to hospice within 30 days or 1 year, or LOS when controlling for sex, age, BMI, smoking status, and ECI (p>0.5). ECI was associated with increased risk of medical complication, re-admission within 30 days, in-hospital mortality/discharge to hospice within 30 days or 1 year, and LOS (p<0.001). Sex (p=0.0445) and BMI (p=0.0058) associated with increased LOS. No regression for SSI was conducted due to inadequate number of cases (N=6, 1.2%). Conclusion: The results of this study show that T2DM patients on a GLP-1RA at the time of HA for FNF are not at a statistically significant risk of a poor outcome after surgery; rather, ECI is more closely associated with a poor outcome after surgery.
Original Publisher
HCA Healthcare Graduate Medical Education
Recommended Citation
Box, McKenna W.; Puga, Troy; Werthmann, Neil; Liu, Yingxian; and Riehl, John T., "Retrospective Cross-Sectional Analysis of GLP-1 Receptor Agonist Effects on Outcomes of Hemiarthroplasty for Femoral Neck Fractures in Diabetics" (2025). North Texas Research Forum 2025. 84.
https://scholarlycommons.hcahealthcare.com/northtexas2025/84
Included in
Nutritional and Metabolic Diseases Commons, Orthopedics Commons, Wounds and Injuries Commons