The Protective Effect of Nrf2 Activation in Cardiovascular Disease

Division

East Florida

Hospital

Aventura Hospital and Medical Center

Document Type

Manuscript

Publication Date

10-21-2019

Keywords

foam cells, free radical, reactive oxygen species, oxidative stress, protandim, respiratory burst

Disciplines

Cardiology | Cardiovascular Diseases

Abstract

The increased mortality of cardiovascular disease (CAD) has been linked with oxidative stress-related chronic inflammation. Current studies are focusing on the importance of reducing oxidative stress to improve outcomes in CAD. Atherosclerosis, a chronic inflammatory disease, has been documented as an underlying cause of myocardial infarction, stroke, and peripheral vascular disease. In this disease, low-density lipoproteins accumulate in the intima layer of the arteries and become oxidized by free radicals. Subsequently, free radicals cause endothelial and smooth muscle damage that is increased by cytokines released by foam cells. These factors are primary contributors to the development of chronic inflammation. Thus, current research is highlighting the significance of measuring and reducing oxidative stress as a fundamental approach to decreasing mortality in cardiovascular disease [1]. This paper reviews the protective effect of Protandim, an Nrf2 activator, in cardiovascular disease.

Publisher or Conference

EC Cardiology

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