Title

Impending Cardiac Tamponade as the Initial Manifestation of BCR-ABL Positive Chronic Myeloid Leukemia

Division

Capital

Hospital

LewisGale-Salem

Document Type

Case Report

Publication Date

8-9-2020

Keywords

cml, bcr-abl positive, cardiac tamponade, pericardial effusion, chronic myeloid leukemia

Disciplines

Cardiology | Hematology | Hemic and Lymphatic Diseases | Neoplasms | Oncology

Abstract

Leukemia involves all organs and tissues of the body. Leukemic infiltration of the pericardium has been documented frequently at post-mortem examinations. Clinically, however, pericardial effusion with cardiac tamponade is rare, and only isolated case reports have been described. In all the reported cases, therapeutic pericardiocentesis was required for the relief of cardiac tamponade with the risk of bleeding since these patients often had deranged hemostasis. We are reporting a rare case of hemorrhagic pericardial effusion in chronic myeloid leukemia before starting the tyrosine kinase inhibitors. The patient required therapeutic pericardiocentesis and hydroxyurea treatment.

Publisher or Conference

Cureus

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