Melanoma Recurrence after Mohs Micrographic Surgery with MART-1: A Systematic Review and Meta-analysis




LewisGale Hospital Montgomery

Document Type

Case Report

Publication Date



melanoma, in situ, cutaneous, invasive, Mohs, micrographic Surgery, MART-1, immunohistochemistry, Dermatology, Dermatological surgery


Dermatology | Neoplasms | Skin and Connective Tissue Diseases | Surgical Procedures, Operative


Background: Surveys suggest wide-spread use of MART-1 in MMS for CM among Mohs surgeons, but no previous systematic review has investigated the efficacy of this specific procedure.

Methods: A systematic search and meta-analysis of retrospective studies on MMS with MART-1 was performed from Pubmed, Medline, and Cochrane databases for articles published from their inception to October 30, 2020. We performed a chi-squared analysis of homogenized data to examine the relationship between recurrence location and rate of recurrence. A risk of bias was obtained with the ROBINS-I tool. [PROSPERO ID: CRD42020221826]

Results: Among the included studies, there were a total of 15 (0.52%) local recurrences of melanoma in-situ and invasive melanoma after MMS with MART-1.

Conclusions: This review has served to demonstrate that MMS with MART-1 immunostaining in frozen sections is a technique that produces satisfactory recurrence rates for melanoma in-situ and invasive melanoma.

Publisher or Conference

Skin: The Journal of Cutaneous Medicine