Superficial CD34 Fibroblastic Tumors and PRDM10-rearranged Soft Tissue Neoplasm: An Evolving Diagnosis
Largo Medical Center
PRDM10, sarcoma, soft tissue neoplasm, superficial CD34+ fibroblastic tumor
Dermatology | Neoplasms
Superficial CD34 fibroblastic tumors (SCD34FT) and PRDM10-rearranged tumors (PRTs) are mesenchymal tumors that have recently received increased scientific attention due to their irrefutable similarities yet debatable relationship. A 74-year-old male presented to the dermatology clinic with a violaceous, well-defined nodule on the left medial knee of 2-year duration. Shave biopsy demonstrated spindle cells arranged in a vaguely storiform pattern forming fascicles. Immunohistochemical stains were positive for vimentin, CD68, CD10, and CD34 diffusely. ERG, S-100, HMB45, and SOX-10 were negative. Molecular studies identified a mediator complex subunit 12 (MED12)-PR/SET Domain 10 (PRDM10) gene fusion thus favoring confirming the diagnosis of a PRT. Our patient underwent wide local excision with negative margins and had no complications. This case aims to provide context for considering SCD34FT and PRT as intersecting entities and to discuss a diagnostic approach when encountering these tumors.
Publisher or Conference
Journal of Cutaneous Pathology
Johnson C, Parsa L, Gibbs J, Sligh J. Superficial CD34 fibroblastic tumors and PRDM10-rearranged soft tissue neoplasm: An evolving diagnosis [published online ahead of print, 2023 May 7]. J Cutan Pathol. 2023;10.1111/cup.14443. doi:10.1111/cup.14443