Cardio-oncology: Capecitabine Can Sometimes be Heatbreaking Capecitabine-Induced Takotsubo Cardiomyopathy Case Report and Literature Review.

Authors

Ramy Abdelmaseih, HCA HealthcareFollow
Anamarys Blanco, HCA HealthcareFollow
Randa Abdelmasih, HCA HealthcareFollow
Krutika Desai, HCA HealthcareFollow
Joshua J. Pothen, HCA HealthcareFollow
Jay Patel, HCA Healthcare
Rama Balaraman, HCA HealthcareFollow

Division

North Florida

Hospital

Ocala Regional Medical Center

Document Type

Case Report

Publication Date

8-1-2021

Keywords

Capecitabine, Humans, Incidence, Neoplasms, Takotsubo Cardiomyopathy

Disciplines

Cardiology | Cardiovascular Diseases | Internal Medicine

Abstract

Capecitabine has been more recognized for its cardiotoxicity with an incidence that varies widely. It demonstrates its toxicity in the forms of acute coronary syndrome, arrhythmias and, to a lesser extent, cardiomyopathy. There are several proposed theories including coronary vasospasm, endothelial injury, and oxidative stress. We present a case of capecitabine-induced cardiomyopathy in a patient with pancreatic cancer and mild coronary artery disease, and shed light on other cardio-toxic agents, their proposed mechanism of cardiotoxicity, and on cardiomyopathy in general.

Publisher or Conference

Current Problems in Cardiology

Recommended Citation

Abdelmaseih R, Blanco A, Abdelmasih R, et al. Cardio-oncology: Capecitabine Can Sometimes be Heatbreaking Capecitabine-Induced Takotsubo Cardiomyopathy Case Report and Literature Review. Curr Probl Cardiol. 2021;46(8):100854. doi:10.1016/j.cpcardiol.2021.100854