Marked Elevation of Carcinoembryonic Antigen Without an Identified Primary Gastrointestinal Tumor
North Florida Regional Medical Center
immunohistochemistry staining, metastatic adenocarcinoma of unknown primary, colorectal, cea, carcinoembryonic antigen
Diagnosis | Internal Medicine | Neoplasms
Whether profound carcinoembryonic antigen (CEA) elevations, such as > 20 times the upper limit of normal, are of diagnostic use remain unknown. Herein, we present a case of a 55-year-old female with profound serum CEA elevation and multiple pelvic masses but with no evidence of a primary gastrointestinal tumor following upper endoscopy and colonoscopy. Subsequent immunostaining of resected pelvic masses confirmed adenocarcinoma of colorectal origin. This case report highlights the possible diagnostic role of profound CEA elevation, particularly in cases of unknown primary tumors.
Publisher or Conference
Salabei JK, Upadhyay D, Haider A, et al. Marked Elevation of Carcinoembryonic Antigen Without an Identified Primary Gastrointestinal Tumor. Cureus. 2021;13(12):e20621. doi:10.7759/cureus.20621