Title

Acute Multiple Sclerosis Exacerbation After Vaccination With the Johnson & Johnson COVID-19 Vaccine: Novel Presentation and First Documented Case Report

Division

East Florida

Hospital

Westside Regional Medical Center

Document Type

Case Report

Publication Date

4-10-2022

Keywords

covid-19 vaccination, multiple sclerosis relapse, allergy and anaphylaxis, infectious disease control, covid 19, johnson & johnson, multiple sclerosis flare-ups

Disciplines

Immune System Diseases | Internal Medicine | Nervous System Diseases

Abstract

Multiple sclerosis (MS) is a neurologic disease caused by a chronic autoimmune process resulting in the demyelination of axons within the central nervous system. MS occurs through combined genetic susceptibility and environmental triggers. MS relapses (MSR) are characterized by acute inflammatory reactions and symptoms. Here we present a novel case of MSR following the second dose of the Johnson & Johnson coronavirus disease 2019 (COVID-19) vaccine (Johnson & Johnson, New Brunswick, New Jersey, United States), presenting with paresthesias and left foot deficit. Additional research and studies are necessary to explore the relationship of COVID-19 vaccinations with MSR.

Publisher or Conference

Cureus

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