Amoxicillin-Clavulanate related Liver Injury
Redmond Regional Medical Center
Drug-Induced Liver Injury, DILI, adverse reactions, abdominal pain
Hepatology | Internal Medicine | Pharmacy and Pharmaceutical Sciences
Recognition of Drug-induced Liver Injury (DILI) may be challenging as it is often diagnosis of exclusion, unavailability of diagnostic test and variability in presentation. Many antibiotics can cause DILI but Amoxicillin-Clavulanate has rare adverse reaction causing mixed cholestatic-hepatocellular injury. Since amoxicillin alone does not induce liver injury, combination of amoxicillin and clavulanic acid could be responsible for this adverse reaction. It can be due to metabolic idiosyncrasy or hypersensitivity mechanism.
Publisher or Conference
American College of Physicians Georgia Chapter
Vaishnani D, et al. Amoxicillin-Clavulanate related Liver Injury. Poster presented at: ACP Georgia Chapter Annual Meeting; October 25-27, 2019; Braselton, GA.