Hypertension-Induced Thrombotic Microangiopathy Leading to End-Stage Renal Disease.
Grand Strand Medical Center
end-stage renal disease, hypertensive emergency, microangiopathic autoimmune hemolytic anemia, thrombotic microangiopathy, tma
Hemic and Lymphatic Diseases | Internal Medicine | Male Urogenital Diseases
Thrombotic microangiopathy (TMA) is a term used for a group of rare and life-threatening hematological conditions. Usually, these disease processes are characterized by microangiopathic hemolytic anemia (MAHA), thrombocytopenia, and microthrombi leading to tissue or organ injury. We present a case of a 41-year-old male with TMA induced by uncontrolled hypertension leading to end-stage renal disease requiring hemodialysis. Our goal is to highlight the importance of distinguishing hypertension-induced thrombotic microangiopathy from other etiologies of TMA, particularly thrombotic thrombocytopenic purpura (TTP), and its effect on renal function despite treatment focused on blood pressure control. Thus, it is a challenging diagnosis for clinicians to determine whether to initiate plasmapheresis for prompt treatment of suspected TTP in the setting of severe hypertension with thrombocytopenia.
Publisher or Conference
Juarez A, Galindo L, Gondal M. Hypertension-Induced Thrombotic Microangiopathy Leading to End-Stage Renal Disease. Cureus. 2023;15(1):e33890. doi:10.7759/cureus.33890