Renal Amyloidosis (AL Kappa Type) With an Uncommon Presentation: A Case Report

Division

North Florida

Hospital

Osceola Regional Medical Center

Document Type

Case Report

Publication Date

3-29-2023

Keywords

hereditary, renal, al amyloidosis, clinical presentation, case report

Disciplines

Internal Medicine | Nephrology | Nutritional and Metabolic Diseases

Abstract

Amyloidosis is a disease associated with deposits of amyloid fibrils that aggregate in various tissues leading to progressive organ failure and often multi-systemic involvement. It may be classified as localized or systemic, acquired or hereditary. Renal presentation is variable but can include nephrotic syndrome, acute renal failure, tubular dysfunction, or just varying degrees of proteinuria. Although most cases of renal amyloidosis are due to acquired causes, in rare instances, the cause can be gene mutations leading to hereditary amyloidosis. We present the case of a 77-year-old Caucasian man diagnosed with renal biopsy-proven AL (kappa) type amyloidosis with isolated renal involvement who had a significant family history of renal biopsy-proven amyloidosis.

Publisher or Conference

Cureus

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