Radiation Proctitis with Recurrent Gastrointestinal Bleeding Complicated by Cytomegalovirus
North Florida Regional Medical Center
radiation proctitis, cytomegalovirus, haematochezia, immunocompetent, recurrent gastrointestinal bleeding
Digestive System Diseases | Infectious Disease | Internal Medicine | Medicine and Health Sciences | Virus Diseases
Cytomegalovirus (CMV) usually causes infections with mild symptoms in immunocompetent individuals. However, in immunocompromised patients, these infections can be serious or life-threatening. Following initial infection, CMV typically becomes dormant but remains lifelong in the host. Reactivation of the latent virus can occur in many organ systems, including the gastrointestinal (GI) tract. Radiation proctitis is a known risk factor associated with prostate radiation, with complicating ulceration and GI bleeding. We present the first case report of an immunocompetent 81-year-old male with multiple episodes of life-threatening GI bleeding, secondary to a non-healing CMV-positive rectal ulcer and CMV colitis following radiation for prostate cancer. Multiple insults including prostate radiation, repeated blood transfusions and CMV infection likely contributed to the recurrent bleeding episodes.
Publisher or Conference
Journal of the Royal College of Physicians of Edinburgh
Auyeung AB, Rayan MN, Tang X, Thomas S. Radiation proctitis with recurrent gastrointestinal bleeding complicated by cytomegalovirus [published online ahead of print, 2023 Oct 31]. J R Coll Physicians Edinb. 2023;14782715231205916. doi:10.1177/14782715231205916