Independent predictors of mortality and 5-year trends in mortality and resource utilization in hospitalized patients with diffuse large B cell lymphoma.


North Florida


North Florida Regional Medical Center

Document Type


Publication Date



comorbidity impact, National Inpatient Sample, healthcare resource utilization, inpatient mortality, trend analysis


Hemic and Lymphatic Diseases | Internal Medicine | Medicine and Health Sciences | Neoplasms


BACKGROUND: This retrospective study analyzed factors influencing all-cause inpatient mortality in 80,930 adult patients (2016-2020) with diffuse large B cell lymphoma using the National Inpatient Sample database.

METHODS: Utilizing ICD-10 codes, patients were identified, and statistical analysis was conducted using STATA. Fisher's exact and Student's

RESULTS: The inpatient mortality rate was found to be 6.56% with a mean age of 67.99 years. Several hospital- and patient-level factors including specific comorbidities such as congestive heart failure, atrial fibrillation, acute kidney injury, chronic obstructive pulmonary disease, liver failure, pancytopenia, tumor lysis syndrome, and severe protein-calorie malnutrition were independently associated with inpatient mortality. Hospitalization costs showed an increasing trend, impacting the overall population and survivors.

CONCLUSION: These insights may refine risk assessment, treatment selection, and interventions.

Publisher or Conference

Baylor University Medical Center Proceedings