Title

Renal Injury in All-Comers After Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis

Division

South Atlantic

Hospital

Orange Park

Document Type

Manuscript

Publication Date

5-6-2020

Keywords

transcatheter aortic valve replacement (tavr), savr, surgical aortic valve replacement, acute kidney injury (aki), renal failure, renal transplant, aortic stenosis

Disciplines

Cardiology | Female Urogenital Diseases and Pregnancy Complications | Internal Medicine | Male Urogenital Diseases | Nephrology | Surgical Procedures, Operative

Abstract

Background

Acute kidney injury (AKI) following aortic valve replacement is associated with poor prognosis. Transcatheter aortic valve replacement (TAVR) is a novel strategy with a percutaneous approach and early recovery time. We conducted this meta-analysis to compare TAVR to surgical aortic valve replacement (SAVR) and their respective renal outcomes.

Methods

We searched for randomized controlled trials (RCTs) using MEDLINE, PUBMED, and Google Scholar databases from their inception till April 6, 2019, and included eight trials comparing TAVR to SAVR in cases that reported AKIs.

Results

We found a significant reduction in AKI after TAVR compared to SAVR at 30 days [n = 66 vs. n = 160, respectively; odds ratio (OR) = 0.38, 95% confidence interval (CI) = 0.28-0.51; p: <0.00001, I2 = 0%]. At one year, a trend towards reduced renal failure was noted in the TAVR arm compared to the SAVR arm (n = 74 vs. n = 129, respectively; OR = 0.57, 95% CI = 0.32-1.01; p = 0.05, I2 = 69%).

Conclusion

Based on our findings and analysis, we have concluded that TAVR is associated with significantly reduced renal injury at 30 days when compared to SAVR.

Publisher or Conference

Cureus

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