Comparing Outcomes of Patients With Idiopathic Subarachnoid Hemorrhage by Stratifying Perimesencephalic Bleeding Patterns.
Computed tomography angiography, Adult, Aged, Disability Evaluation, Female, Health Status, Humans, Length of Stay, Male, Middle Aged, Predictive Value of Tests, Prognosis, Recovery of Function, Retrospective Studies, Risk Factors, Subarachnoid Hemorrhage, Time Factors, Tomography, X-Ray Computed
Cardiovascular Diseases | Diagnosis | Medicine and Health Sciences | Nervous System Diseases | Neurology | Pathological Conditions, Signs and Symptoms
BACKGROUND: To determine the clinical outcomes of perimesencephalic subarachnoid hemorrhages based on the computed tomography (CT) bleeding patterns.
METHODS: This retrospective cohort study included: (1) patients (≥18 years) admitted to a comprehensive stroke center (January 2015-May 2018), (2) with angiography-negative, nontraumatic subarachnoid hemorrhage in a perimesencephalic or diffuse bleeding pattern, and (3) had CT imaging performed in ≤ 72 hours of symptom onset. Patients were stratified by location of bleeding on CT: Peri-1: focal prepontine hemorrhage; Peri-2: prepontine with suprasellar cistern +/- intraventricular extension; and diffuse.
RESULTS: Of the 39 patients included, 13 were Peri-1, 11 were Peri-2, and 15 were diffuse. The majority were male (n = 26), with a mean (standard deviation) age of 55.3 (11.3) years, who often presented with headache (n = 37) and nausea (n = 28). Overall, patients in Peri-1 were significantly less likely to have hydrocephalus compared to Peri-2 and dSAH (P= .003), and 4 patients required an external ventricular drain. Five patients developed symptomatic vasospasm. Patients in Peri-1, compared to Peri-2 and diffuse, had a significantly shorter median neuro critical care unit length of stay (LOS) and hospital LOS. Most patients (n = 35) had a discharge modified Rankin Score between 0 and 2 with no significant differences found between groups.
CONCLUSION: These data suggest that patients with the best clinical course were those in Peri-1, followed by Peri-2, and then diffuse. Because these patients often present with similar clinical signs, stratifying by hemorrhage pattern may help clinicians predict which patients with perimesencephalic subarachnoid hemorrhage develop complications.
Publisher or Conference
Journal of Stroke and Cerebrovascular Diseases
Atchie B, McGraw C, McCarthy K, van Vliet R, Frei D, Bennett A, Bartt R, Orlando A, Wagner J, Bar-Or D. Comparing Outcomes of Patients With Idiopathic Subarachnoid Hemorrhage by Stratifying Perimesencephalic Bleeding Patterns. J Stroke Cerebrovasc Dis. 2019 Sep;28(9):2407-2413. doi: 10.1016/j.jstrokecerebrovasdis.2019.06.032. Epub 2019 Jul 12. PubMed PMID: 31303438.