University Hospital & Medical Center
EPS, extrapyramidal symptoms, tardive dyskinesia, dyskinesias
Nervous System Diseases | Neurology | Pathological Conditions, Signs and Symptoms
Extrapyramidal symptoms (EPS) were first witnessed in the 1950s following the discovery of the then-novel class of medication known as neuroleptics. Manifestations of EPS were first officially reported at the “Swiss Symposium on Chlorpromazine” in 1953. The therapeutic efficacy of this new drug class, in parallel with its extrapyramidal activity, resulted in the designation of the term “neuroleptic,” as these drugs were primarily thought to aid in calming psychomotor agitation. It was initially thought EPS manifested promptly after neuroleptic administration. However, subsequent latent motor abnormalities would challenge these assumptions.
Publisher or Conference
Fariba K, Estevez R. Tardive Dystonia. [Updated 2020 Jul 5]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK559019/