Title

Tardive Dystonia

Division

East Florida

Hospital

University

Document Type

Review Article

Publication Date

7-5-2020

Keywords

EPS, extrapyramidal symptoms, tardive dyskinesia, dyskinesias

Disciplines

Nervous System Diseases | Neurology | Pathological Conditions, Signs and Symptoms

Abstract

Excerpt


Extrapyramidal symptoms (EPS) were first witnessed in the 1950s following the discovery of the then-novel class of medication known as neuroleptics.[1] Manifestations of EPS were first officially reported at the “Swiss Symposium on Chlorpromazine” in 1953.[2] The therapeutic efficacy of this new drug class, in parallel with its extrapyramidal activity, resulted in the designation of the term “neuroleptic,” as these drugs were primarily thought to aid in calming psychomotor agitation.[3] It was initially thought EPS manifested promptly after neuroleptic administration. However, subsequent latent motor abnormalities would challenge these assumptions.

Publisher or Conference

StatPearls

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