Cryptococcal Meningoencephalitis 10 Years After Bone Marrow Transplant in a Patient With Multiple Myeloma
Medical Center of Trinity
cryptococcus, cryptococcal meningoencephalitis, encephalitis, meningoencephalitis
Bacterial Infections and Mycoses | Infectious Disease | Internal Medicine | Neurology
Cryptococcosis is a fungal infection that mostly affects immunocompromised patients. Diagnosis is based on the detection of cryptococcal antigen in the cerebrospinal fluid (CSF) or serum. Antifungal resistance is emerging, making treatment difficult and long. We report a case of cryptococcosis in a patient with multiple myeloma, years after undergoing a bone marrow transplant. Symptoms were mild, and imaging studies were nonspecific. CSF analysis revealed positive cryptococcal antigen. The patient was started on the standard three-phase antifungal therapy and recovered.
Publisher or Conference
Stepman G, Sanapati J, Dabb K, et al. Cryptococcal Meningoencephalitis 10 Years After Bone Marrow Transplant in a Patient With Multiple Myeloma. Cureus. 2020 Dec 14;12(12):e12094. doi:10.7759/cureus.12094