Sex disparities in cardiovascular disease outcomes among geriatric patients with prediabetes.

Authors

Hee Kong Fong, UC DavisFollow
Rupak Desai, Atlanta VA Medical CenterFollow
Mohammed Faisaluddin
Tarang Parekh, George Mason UniversityFollow
Ahmed Mahmood, HCA HealthcareFollow
Vraj Shah
Priyal Shah
Vaishnavi Reddy Varakantam
Falah Abu Hassan
Sejal Savani
Rajkumar DoshiFollow
Kishorbhai GanganiFollow

Division

Mountain

Hospital

Eastern Idaho Regional Medical Center

Document Type

Manuscript

Publication Date

7-3-2020

Keywords

Cardiovascular disease; Gender/sex disparity; Geriatrics; Older; Prediabetes.

Disciplines

Cardiology | Cardiovascular Diseases | Endocrine System Diseases

Abstract

AIMS: To analyze the sex-based differences in the prevalence of cardiovascular disease risk factors and outcomes in older patients with prediabetes using demographically matched national cohorts of hospitalized patients aged ≥65 years.

METHODS: We queried the 2007-2014 National Inpatient Database to identify older patients (>65 years) admitted with prediabetes using ICD-9 Clinical Modification codes. The older patients were then subcategorized based on sex. Comparative analyses of their baseline characteristics, the prevalence of cardiovascular(CV) disease comorbidities, hospitalization outcomes, and mortality rates were performed on propensity-matched cohorts for demographics.

RESULTS: A total of 1,197,978 older patients with prediabetes (599,223 males; mean age 75years and 598,755 females; mean age 76years) were identified. Higher admission rates were found commonly among older white males (84.1%) and females (81.7%). Prediabetic older males showed a higher frequency of cardiovascular comorbidities compared to females. Prediabetic older males had higher all-cause in-hospital mortality (4.2% vs. 3.6%, p < 0.001), acute myocardial infarction (7.0% vs. 4.7%, p < 0.001), arrhythmia (36.3% vs. 30.5%, p < 0.001), stroke (4.8% vs. 4.6%, p < 0.001), venous thromboembolism (3.3% vs. 3.0%, p < 0.001) and percutaneous coronary intervention (3.1% vs. 1.5%, p < 0.001) compared to females.

CONCLUSIONS: Our analysis revealed that among older patients hospitalized with prediabetes, males suffered worse in-hospital CV outcomes and survival rates compared to females.

Publisher or Conference

Primary Care Diabetes

Recommended Citation

Fong HK, Desai R, Faisaluddin M, et al. Sex disparities in cardiovascular disease outcomes among geriatric patients with prediabetes [published online ahead of print, 2020 Jul 3]. Prim Care Diabetes. 2020;S1751-9918(20)30217-5. doi:10.1016/j.pcd.2020.06.005