SARS-CoV-2: Current Tools to Fight COVID-19 ST-Elevation Myocardial Infarction.

Division

Far West

Hospital

Riverside Community Hospital

Document Type

Manuscript

Publication Date

8-15-2023

Keywords

balloon pump, coronary stent, covid 19, impella device, mechanical thrombectomy (mt), myocardial infarction, percutaneous cardiac intervention, st-elevation myocardial infarction (stemi), thrombolytic, thrombus

Disciplines

Cardiology | Cardiovascular Diseases | Internal Medicine | Virus Diseases

Abstract

The capacity of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to wreak havoc on the inflammatory and coagulation pathways via the cytokine storm has led to over 6.3 million fatalities globally. Based on recent data, the mechanism predominately involves the formation of microvascular thrombosis when pertaining to cardiovascular disease. However, a subset of coronavirus disease-2019 (COVID-19)-positive patients present emergently with acute ST-elevation myocardial infarction (STEMI) are found to have severe epicardial thrombosis which is refractory to traditional coronary revascularization. We have noted mortality in these patients presenting to our facility to be as high as 90% and all angiographically confirmed to have thrombus which was refractory to traditional therapy. We present a case series of COVID-19-positive patients presenting with STEMI found to have epicardial thrombus who were treated with different traditional STEMI therapies but with fatal outcomes. Other possible techniques including mechanical thrombectomy, optimizing traditional and nontraditional anticoagulation therapy with the use of early hemodynamic support may prove more efficacious to destroy thrombus and potentially improve mortality.

Publisher or Conference

Cureus

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