Facial Skin Manifestation of a Destructive, Nonkeratinizing Squamous Cell Carcinoma.

Division

West Florida

Hospital

Largo Medical Center

Document Type

Case Report

Publication Date

8-13-2024

Keywords

aggressive destructive lesion, hpv-related oropharyngeal cancer, nasopharyngeal biopsy, p16 testing, squamous cell carcinoma

Disciplines

Dermatology | Medicine and Health Sciences | Neoplasms | Otorhinolaryngologic Diseases | Skin and Connective Tissue Diseases

Abstract

Nonkeratinizing squamous cell carcinoma (NKSCC) of the sinonasal tract is a rare malignancy that infrequently presents with cutaneous extension. This case describes an unusual instance of extensive facial skin involvement in an elderly male with multiple comorbidities, diagnosed with a biopsy-proven NKSCC. The tumor was p16 positive, suggesting an HPV-related etiology. This case emphasizes the critical role of dermatologists in the early diagnosis and multidisciplinary management of such aggressive tumors. It highlights the necessity of including NKSCC in the differential diagnosis of destructive facial tumors. Dermatologists should remain vigilant for rare presentations and employ early biopsy and histopathological examinations to facilitate prompt multidisciplinary intervention. Recognizing p16 positivity can indicate a human papillomavirus (HPV)-related etiology, potentially influencing prognosis and management strategies.

Publisher or Conference

Cureus

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