Intraparenchymal Hematoma With Significant Mass Effect Treated With Factor Eight Inhibitor Bypass Activity

Division

North Florida

Hospital

Osceola Regional Medical Center

Document Type

Case Report

Publication Date

11-11-2022

Keywords

factor eight inhibitor bypass activity, prothrombin complex concentrate, andexanet alfa, fresh frozen plasma, intraparenchymal hematoma

Disciplines

Emergency Medicine | Hemic and Lymphatic Diseases

Abstract

The authors present the case of an 80-year-old female with myelodysplastic syndrome treated with chemotherapy and apixaban, a direct oral anticoagulant who suffered an intracranial hemorrhage. She presented to the emergency department with altered mental status and was found to have a large intraparenchymal hematoma with a significant mass effect. Our patient was given FEIBA (Factor Eight Inhibitor Bypass Activity) to reverse the hemorrhage. Anticoagulant-related bleeding reversal strategies are discussed.

Publisher or Conference

Cureus

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