Dexmethylphenidate-Induced Rhabdomyolysis by Interaction With Aromatase Inhibitor

Division

North Florida

Hospital

Ocala Regional Medical Center

Document Type

Case Report

Publication Date

8-14-2022

Keywords

amphetamine-dextroamphetamine, aromatase inhibitor, attention deficit hyperactivity disorder (adhd), dexmethylphenidate, growth hormone replacement therapy, letrozole, non-traumatic rhabdomyolysis, pituitary hormone replacement

Disciplines

Emergency Medicine | Musculoskeletal Diseases

Abstract

Rhabdomyolysis secondary to prescription drug-drug interactions can be an overlooked life-threatening emergency. Amphetamines and similar substances have been associated with muscle lysis secondary to increased sympathetic activity that can cause myotoxicity, hyperthermia, and increased muscular activity. Anabolic steroids may also be a predisposing factor in developing rhabdomyolysis. A high index of suspicion for drug-induced rhabdomyolysis in a patient presenting with atraumatic extremity pain can facilitate rapid diagnosis and treatment. We present a case of drug-induced rhabdomyolysis likely secondary to a previously unreported medication interaction.

Publisher or Conference

Cureus

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