Role of Cholecystectomy in Hyperkinetic Biliary Dyskinesia: A Systematic Review and Meta-Analysis

Division

Gulf Coast

Hospital

HCA Houston Healthcare Kingwood

Document Type

Manuscript

Publication Date

6-3-2025

Keywords

Biliary hyperkinesia, Cholecystectomy, Hyperkinetic biliary dyskinesia, Hyperkinetic gallbladder

Disciplines

Digestive System Diseases | Medicine and Health Sciences | Surgery

Abstract

BACKGROUND: Biliary dyskinesia is disorder characterized by reduced gallbladder ejection fraction, which have shown a good response to cholecystectomy. In contrast, hyperkinetic biliary dyskinesia (HBD), as defined by ejection fraction ≥80 %, is an emerging phenomenon, and the role of cholecystectomy is not yet clearly defined. This review investigates the effectiveness of cholecystectomy in alleviating symptoms of HBD.

MATERIAL AND METHODS: A comprehensive literature search was conducted to retrieve studies based on predefined inclusion criteria. Data were extracted by two-independent reviewers. A random-effects model was used for meta-analysis. Risk ratios (RR) were calculated to estimate the impact of cholecystectomy on symptom improvement. Heterogeneity was calculated using the I

RESULTS: Fourteen studies involving 416 patients with HBD were included. Overall, the pooled RR for symptom relief post-cholecystectomy was 3.72 (95 % CI: 2.57-5.38). A subgroup analysis of retrospective reviews showed an RR of 3.9 (95 % CI: 2.57-5.92). Moderate heterogeneity (I

CONCLUSION: Based on existing evidence, cholecystectomy appeared to be a promising and effective treatment for HBD in select patients.

Publisher or Conference

Surgery Open Science

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