Skin Adnexal Tumor Pilomatrix Disease: A Transformation from Benign to Malignant

Division

West Florida

Hospital

Regional Medical Center Bayonet Point

Document Type

Case Report

Publication Date

9-1-2025

Keywords

adnexal tumors, pilomatricoma, pilomatrix carcinoma, surgical oncology

Disciplines

Medicine and Health Sciences | Neoplasms | Pathology | Skin and Connective Tissue Diseases | Surgery

Abstract

Skin adnexal tumors are a wide category of both benign and malignant neoplasms that exhibit morphologic differentiation into one or more than one type of adnexal structure of the skin. We present here a unique finding of a large pilomatrix carcinoma (PC) of the upper extremity in a 54 year-old-man, initially believed to be a pilomatricoma (PM). He underwent surgical excision and lymph node biopsy successfully without any complications followed by reconstructive skin grafting. Imaging and initial pathology supported a benign diagnosis, however further tissue analysis revealed a malignant PC with evidence of matrical differentiation, increased mitotic activity, and central necrosis. Our patient's disease course may support the theory that benign PM are the origin of formation of PCs. Furthermore, this case report will discuss the histology, epidemiology, and evolving pathogenesis of these adnexal tumors.

Publisher or Conference

Journal of Surgical Case Reports

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