Completion Lymph Node Dissection in Patients with Sentinel Lymph Node Positive Cutaneous Head and Neck Melanoma

Division

West Florida

Hospital

Brandon Regional Hospital

Document Type

Manuscript

Publication Date

7-11-2020

Keywords

melanoma, neuroendocrine tumors, sentinel lymph node biopsy, lymph node excision

Disciplines

Neoplasms | Oncology | Surgery | Surgical Procedures, Operative

Abstract

Background

Relatively few cutaneous head and neck melanoma (CHNM) patients with were included in the multicenter selective lymphadenectomy trial II (MSLT‐II). Our objective was to investigate whether immediate completion lymph node dissection completion of lymph node dissection (CLND) was associated with survival benefit for sentinel lymph node (SLN) positive CHNM using the National Cancer Database.

Methods

SLN positive patients with CHNM from 2012 to 2014 were retrospectively analyzed. Patients were divided into two groups: those who underwent SLN biopsy (SLNB) only versus those who underwent SLNB followed by CLND (SLNB + CLND). The primary outcome was 5‐year overall survival (OS).

Results

Among 530 SLNB + patients, 342 patients underwent SLNB followed by CLND (SLNB + CLND). The SLNB only group had fewer positive SLN, less advanced pathologic stage, and a lower rate of adjuvant immunotherapy. There was no significant difference in 5‐year OS between the two groups (51.0% vs 67%; P  = .56). After adjusting for pathologic stage, there remained no difference in 5‐year OS among patients with stage IIIA (63.0% vs. 73.6%, P  = 0.22) or IIIB/IIIC disease (39.1% vs 57.8%; P  = .52).

Conclusions

Using a large nationwide database, CLND was not shown to be associated with improved OS for patients with SLNB positive CHNM, validating the results of MSLT‐II.

Publisher or Conference

Journal of Surgical Oncology

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