Atypical Mycobacterial Tenosynovitis in the Setting of Adalimumab Use

Division

South Atlantic

Hospital

Orange Park Medical Center

Document Type

Case Report

Publication Date

10-21-2021

Keywords

psoriasis, musculoskeletal, tenosynovitis, adalimumab, nontuberculous mycobacterium

Disciplines

Bacterial Infections and Mycoses | Infectious Disease | Internal Medicine

Abstract

Tumor necrosis factor-alpha (TNF-α) inhibitors indicated in the management of psoriasis, rheumatoid arthritis, ulcerative colitis, Crohn’s disease, and other autoimmune diseases have been associated with the development of mycobacterial and other opportunistic infections. The majority of mycobacterial infections diagnosed in patients taking TNF-α inhibitors are secondary to Mycobacterium tuberculosis. Atypical mycobacteria have also been identified in this patient population, most commonly manifested by pulmonary or disseminated infections. Extra-pulmonary manifestations such as bone and joint infections are rare. We describe a case of atypical mycobacterial tenosynovitis in the setting of adalimumab use in a patient with psoriasis. This is a rarely reported complication that one should be aware of when prescribing these medications.

Publisher or Conference

Cureus

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