Zieve Syndrome in a Patient With Hepatitis C

Division

North Florida

Hospital

North Florida Regional Medical Center

Document Type

Case Report

Publication Date

5-27-2022

Keywords

chronic liver disease (cld), alcohol use, hepatitis c (hcv) infection, alcohol-related liver disease, s: anemia, acute hemolytic anemia, zieve's disease, zieve syndrome

Disciplines

Digestive System Diseases | Internal Medicine

Abstract

Zieve syndrome is a very rare syndrome that presents as a triad of hemolytic anemia, jaundice, and transient hyperlipidemia in patients with alcoholic liver disease. Herein, we present a case of a 30-year-old female with alcoholic liver disease and chronic hepatitis C. She presented with altered mental status and profound jaundice and was subsequently found to have acute hemolytic anemia due to Zieve syndrome. All other causes of hemolytic anemia were ruled out. She abstained from alcohol and received blood transfusions as needed, leading to the improvement of her anemia. This case highlights the need for more medical education about Zieve syndrome as the under-recognition of the disease can lead to unnecessary treatments. We review the existing literature to explain the epidemiology, pathogenesis, diagnosis, and treatment of Zieve syndrome. This case represents a rare presentation of Zieve syndrome in a patient with hepatitis C, and we have hypothesized a possible role of chronic hepatitis C infection in its pathophysiology.

Publisher or Conference

Cureus

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