Diagnosis of the Primary Tumor Site in the Case of Liver Metastatic Carcinoma.

Division

North Florida

Hospital

North Florida Regional Medical Center

Document Type

Case Report

Publication Date

7-12-2022

Keywords

hepatic malignancy, immunohistochemistry staining, lung adenocarcinoma, metastatic adenocarcinoma of unknown primary, non-cirrhotic liver

Disciplines

Internal Medicine | Neoplasms | Pathology

Abstract

Immunohistochemical markers have been frequently utilized as a diagnostic tool in pathology to help in diagnosing malignancy of unknown primary sites. In previous cases, the immunohistological expression of cytokeratin 7 (CK7), Napsin A, and thyroid transcription factor-1 (TTF-1) has helped identify and diagnose primary malignancy as originating from the lung. This case report describes an elderly woman with a liver metastasis consistent with a lung primary and illustrates the utility and importance of tissue-specific markers as a diagnostic tool in the evaluation of unknown primary tumors.

Publisher or Conference

Cureus

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