Diagnosis of the Primary Tumor Site in the Case of Liver Metastatic Carcinoma.
North Florida Regional Medical Center
hepatic malignancy, immunohistochemistry staining, lung adenocarcinoma, metastatic adenocarcinoma of unknown primary, non-cirrhotic liver
Internal Medicine | Neoplasms | Pathology
Immunohistochemical markers have been frequently utilized as a diagnostic tool in pathology to help in diagnosing malignancy of unknown primary sites. In previous cases, the immunohistological expression of cytokeratin 7 (CK7), Napsin A, and thyroid transcription factor-1 (TTF-1) has helped identify and diagnose primary malignancy as originating from the lung. This case report describes an elderly woman with a liver metastasis consistent with a lung primary and illustrates the utility and importance of tissue-specific markers as a diagnostic tool in the evaluation of unknown primary tumors.
Publisher or Conference
Malone M, Bray C, Liu XS. Diagnosis of the Primary Tumor Site in the Case of Liver Metastatic Carcinoma. Cureus. 2022;14(7):e26782. doi:10.7759/cureus.26782