Association of Dementia and Patient Outcomes Among COVID-19 Patients: A Multi-Center Retrospective Case-Control Study




TriStar Centennial Medical Center

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COVID-19, baseline characteristics, dementia, intensive care unit (ICU), mortality


Critical Care | Internal Medicine | Nervous System Diseases | Psychiatry | Psychiatry and Psychology | Virus Diseases


BACKGROUND: We conducted a retrospective cohort study on COVID-19 patients with and without dementia by extracting data from the HCA Healthcare Enterprise Data Warehouse between January-September 2020.

AIMS: To describe the role of patients' baseline characteristics specifically dementia in determining overall health outcomes in COVID-19 patients.

METHODS: We grouped in-patients who had ICD-10 codes for dementia (DM) with age and gender-matched (1:2) patients without dementia (ND). Our primary outcome variables were in-hospital mortality, length of stay, Intensive Care Unit (ICU) admission, ICU-free days, mechanical ventilation (MV) use, MV-free days and 90-day re-admission.

RESULTS: Matching provided similar age and sex in DM and ND groups. BMI (median, 25.8 vs. 27.6) and proportion of patients who had smoked (23.3 vs. 31.3%) were lower in DM than in ND patients. The median (IQR) Elixhauser Comorbidity Index was higher in dementia patients 7 (5-10) vs. 5 (3-7,

CONCLUSIONS: Our data showed that COVID-19 patients with dementia did not fare substantially worse, but in fact, fared better when certain metrics were considered.

Publisher or Conference

Frontiers in Medicine: Geriatric Medicine