Acute Typhlitis: A Rare Complication of FOLFIRINOX Chemotherapy in the Treatment of Advanced Pancreatic Cancer
Grand Strand Medical Center
FOLFIRINOX, Typhlitis, Neutropenic enterocolitis, Pancreatic cancer
Digestive System Diseases | Internal Medicine | Neoplasms
FOLFIRINOX is a combination of multiple chemotherapeutic agents, commonly used to treat metastatic pancreatic cancer . A less commonly associated side-effect to this chemotherapy regimen is typhlitis, also known as neutropenic enterocolitis (NEC). This is a life-threatening condition that occurs secondary to cytotoxic damage of the gastrointestinal mucosal wall, particularly the cecum . This loss of mucosal wall integrity subsequently leads to infection and inflammation. As such, immunosuppressed patients exposed to highly cytotoxic agents are of higher risk for translocation of gut bacteria and eventually septic shock. Our case report reviews the diagnosis, management and impact of typhlitis secondary to FOLFIRINOX therapy. Typhlitis should always be suspected when a patient undergoing active chemotherapy presents to an acute care facility with Right Lower Quadrant (RLQ) abdominal pain, fever and neutropenia. Nonetheless, this life-threatening diagnosis is often missed.
Publisher or Conference
International Journal of Clinical Studies and Medical Case Reports
Traylor C, Check L, Faris M. Acute Typhlitis: A Rare Complication of FOLFIRINOX Chemotherapy in the Treatment of Advanced Pancreatic Cancer. IJCMCR. 2022;20(4):002. doi: 10.46998/IJCMCR.2022.20.000492