Antithrombotics and Gastrointestinal Prophylaxis: A Systematic Review.

Division

West Florida

Hospital

Largo Medical Center

Document Type

Manuscript

Publication Date

3-17-2023

Keywords

antithrombotic medications, gastrointestinal bleeding, prophylaxis

Disciplines

Cardiovascular Diseases | Internal Medicine

Abstract

Antithrombotic medications include both antiplatelet and anticoagulants and are used for a wide variety of cardiovascular conditions. A common complication of antithrombotic use is gastrointestinal bleeding. As a result, gastrointestinal prophylaxis is a common consideration for patients on a single or combination antithrombotic regimen. Prophylaxis is typically achieved through use of either proton pump inhibitors or histamine 2 receptor antagonists. Current recommendations for use of gastrointestinal prophylaxis with concomitant use of antithrombotic medications are scarce. In this systematic review, we explore the current evidence and recommendations regarding gastrointestinal prophylaxis for patients on antiplatelet or anticoagulant therapy as well as combination regimens.

Publisher or Conference

Cardiology in Review

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