Probiotic-Associated Central Venous Catheter Bloodstream Infections Lead to Increased Mortality in the ICU

Division

Continental

Hospital

Sky Ridge Medical Center

Document Type

Manuscript

Publication Date

6-1-2023

Keywords

central venous catheter, sepsis, bloodstream infections, probiotics

Disciplines

Bacterial Infections and Mycoses | Critical Care | Internal Medicine | Pathological Conditions, Signs and Symptoms

Abstract

OBJECTIVES: To determine the occurrence rate and impact on patient outcomes of probiotic-associated central venous catheter bloodstream infections in the ICU.

DESIGN: Retrospective observational cohort study.

SETTING: The cohort was gathered using HCA Healthcare's data warehouse.

PATIENTS: Adult patients with central venous catheters in the ICU.

INTERVENTIONS: None.

MEASUREMENTS AND MAIN RESULTS: Blood culture data were used to determine whether an infection had occurred with an organism contained in an administered probiotic. Eighty-six probiotic-associated central venous catheter bloodstream infections were identified among the 23,015 patient cohort who received probiotics (0.37%). The number needed to harm was 270. Zero infections were found in the cohort that did not receive probiotics. Patients who contracted a probiotic infection had increased mortality (odds ratio, 2.23; 1.30-3.71; p < 0.01). Powder formulations had an increased rate of infection compared with nonpowder formulations (0.76% vs 0.33%; odds ratio, 2.03; 1.05-3.95; p = 0.04).

CONCLUSIONS: Probiotic administration is associated with a substantial rate of probiotic-associated bloodstream infection in ICU patients with central venous catheters in place. Probiotic-associated bloodstream infections result in significantly increased mortality. Powder formulations cause bloodstream infections more frequently than nonpowder formulations. In ICU patients with central venous catheters, the risks of probiotic-associated central venous catheter bloodstream infection and death outweigh any potential benefits of probiotic administration.

Publisher or Conference

Critical Care Medicine

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