Probiotic-Associated Central Venous Catheter Bloodstream Infections Lead to Increased Mortality in the ICU
Sky Ridge Medical Center
central venous catheter, sepsis, bloodstream infections, probiotics
Bacterial Infections and Mycoses | Critical Care | Internal Medicine | Pathological Conditions, Signs and Symptoms
OBJECTIVES: To determine the occurrence rate and impact on patient outcomes of probiotic-associated central venous catheter bloodstream infections in the ICU.
DESIGN: Retrospective observational cohort study.
SETTING: The cohort was gathered using HCA Healthcare's data warehouse.
PATIENTS: Adult patients with central venous catheters in the ICU.
MEASUREMENTS AND MAIN RESULTS: Blood culture data were used to determine whether an infection had occurred with an organism contained in an administered probiotic. Eighty-six probiotic-associated central venous catheter bloodstream infections were identified among the 23,015 patient cohort who received probiotics (0.37%). The number needed to harm was 270. Zero infections were found in the cohort that did not receive probiotics. Patients who contracted a probiotic infection had increased mortality (odds ratio, 2.23; 1.30-3.71; p < 0.01). Powder formulations had an increased rate of infection compared with nonpowder formulations (0.76% vs 0.33%; odds ratio, 2.03; 1.05-3.95; p = 0.04).
CONCLUSIONS: Probiotic administration is associated with a substantial rate of probiotic-associated bloodstream infection in ICU patients with central venous catheters in place. Probiotic-associated bloodstream infections result in significantly increased mortality. Powder formulations cause bloodstream infections more frequently than nonpowder formulations. In ICU patients with central venous catheters, the risks of probiotic-associated central venous catheter bloodstream infection and death outweigh any potential benefits of probiotic administration.
Publisher or Conference
Critical Care Medicine
Mayer S, Bonhag C, Jenkins P, Cornett B, Watts P, Scherbak D. Probiotic-Associated Central Venous Catheter Bloodstream Infections Lead to Increased Mortality in the ICU. Crit Care Med. 2023;10.1097/CCM.0000000000005953. doi:10.1097/CCM.0000000000005953