Acute Colonic Perforation with Septic Shock Secondary to Disseminated Histoplasmosis in an Autologous Bone Marrow Transplant Recipient

Authors

Harsimrandeep Bhatti, HCA HealthFollow
Enkhbileg Batbileg, HCA HealthcareFollow
Srijisnu De, HCA HealthcareFollow
Glen Friedman, HCA HealthcareFollow
Suresh Antony, HCA HealthcareFollow

Division

Central and West Texas

Hospital

Del Sol Medical Center

Document Type

Case Report

Publication Date

5-16-2023

Keywords

bone marrow transplant, colonic perforation, disseminated histoplasmosis, infectious disease, pancytopenia, surgery

Disciplines

Bacterial Infections and Mycoses | Infectious Disease | Internal Medicine

Abstract

Histoplasma capsulatum is an opportunistic pathogen which can lead to a wide variety of clinical presentations in the immunocompromised host. Post-transplant histoplasmosis in hematopoietic cell transplant recipients is exceedingly rare, with an incidence of <1%. We present a case of acute caecal perforation resulting from disseminated histoplasmosis in a patient who had undergone autologous bone marrow transplant for plasma cell dyscrasia. This is a 71-year-old patient who initially presented due to progressive weakness associated with shortness of breath.

Publisher or Conference

Infection and Drug Resistance

Recommended Citation

Bhatti H, Batbileg E, De S, Friedman G, Antony S. Acute Colonic Perforation with Septic Shock Secondary to Disseminated Histoplasmosis in an Autologous Bone Marrow Transplant Recipient. Infect Drug Resist. 2023;16:3029-3034. doi:10.2147/IDR.S402228