Incidental Skin Manifestation of Trisomy 12 Chronic Lymphocytic Leukemia

Division

Far West

Hospital

MountainView Hospital

Document Type

Abstract

Publication Date

2023

Keywords

Chronic lymphocytic leukemia, Trisomy 12, CD5 B-cell, Flow cytometry, Leukemia cutis

Disciplines

Congenital, Hereditary, and Neonatal Diseases and Abnormalities | Hemic and Lymphatic Diseases | Internal Medicine | Neoplasms

Abstract

Chronic lymphocytic leukemia (CLL) is one of the most prevalent B-cell cancers for people over the age of 65. CLL is commonly comorbid with trisomy 12, as reported in up to 20% of cases. In our case, trisomy 12 was incidentally found on this patient. Its pathophysiology is quite unclear but has played a role in the side effect profile of CLL. Trisomy 12 with CLL has been shown to have increased risk for side effects like thrombocytopenia, Richter transformation and hematological cancers. The goal of this case presentation is to discuss a case of CLL with cutaneous manifestations and to look at the role that trisomy 12 can play.

Publisher or Conference

World Journal of Advanced Research and Reviews

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