The First Case of Daratumumab-Induced Fulminant Hepatic Failure

Division

East Florida

Hospital

Westside Regional Medical Center

Document Type

Case Report

Publication Date

10-11-2023

Keywords

acute fulminant liver failure, chemotherapy, daratumumab, drug induced, thrombocytopenia

Disciplines

Digestive System Diseases | Internal Medicine | Medicine and Health Sciences

Abstract

Drug-induced liver failure is a relatively uncommon condition with a vast spectrum of clinical manifestations, and it is a leading cause of acute hepatic failure in the United States. We describe the first case of fulminant hepatic failure induced by chemotherapeutic drug daratumumab, a common FDA-approved agent. A 77-year-old male, with a history of multiple myeloma, was admitted for left lower extremity cellulitis, two weeks after receiving his first intravenous infusion of daratumumab. He developed fulminant hepatic failure in the hospital a few days later. Despite multiple doses of N-acetylcysteine, his liver function continued to decline, and he expired shortly after.

Publisher or Conference

Cureus

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