A Case of Type 1 Cryoglobulinemia With Lymphoplasmacytic Lymphoma and Dry Gangrene

Division

South Atlantic

Hospital

Trident Medical Center

Document Type

Case Report

Publication Date

1-21-2024

Keywords

chemotherapy, chemotherapy response, gangrene, plasmapharesis, vascular occlusion

Disciplines

Hemic and Lymphatic Diseases | Internal Medicine | Medicine and Health Sciences | Neoplasms

Abstract

Lymphoplasmacytic lymphoma (LPL) is an uncommon condition, accounting for only 2% of all non-Hodgkin's lymphoma cases. Individuals with LPL face the risk of vascular blockage when associated with type I cryoglobulinemia, leading to related symptoms. Until now, no instances of LPL with dry gangrene have been documented. However, we present a rare case involving LPL accompanied by dry gangrene in both the right upper extremity (RUE) and left lower extremity (LLE). The patient was effectively managed using a combination of chemotherapy, steroids, plasmapheresis, and salvage surgery.

Publisher or Conference

Cureus

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