Semaglutide-Induced Liver Injury

Division

North Florida

Hospital

North Florida Regional Medical Center

Document Type

Manuscript

Publication Date

8-4-2025

Keywords

GLP-1 receptor agonists, drug-induced liver injury, hepatotoxicity, semaglutide

Disciplines

Digestive System Diseases | Gastroenterology | Internal Medicine | Medicine and Health Sciences

Abstract

Semaglutide, a glucagon-like peptide-1 receptor agonist widely used for managing type 2 diabetes mellitus and obesity. Reports of semaglutide-associated hepatotoxicity are exceedingly rare. We detail a case of a 44-year-old woman who developed liver injury with elevated liver enzymes after semaglutide initiation for weight management. Liver enzyme levels normalized after discontinuing the drug and worsened upon rechallenge, confirming semaglutide's potential to cause liver injury. In addition, our case study encompasses a literature review of all reported semaglutide-related drug-induced liver injury cases, highlighting the need for diligent liver function monitoring in patients on semaglutide and offering valuable insights into its hepatotoxic potential.

Publisher or Conference

ACG Case Reports Journal

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