Effectiveness of Pharmacotherapy and Technical Modifications as Adjunctive Tools for Enhancing Weight Loss After Bariatric Endoscopy (Endoscopic Gastric Remodeling and Transoral Outlet Reduction): A Meta-analysis

Division

North Florida

Hospital

Ocala Regional Medical Center

Document Type

Manuscript

Publication Date

8-1-2025

Keywords

Humans, Weight Loss, Obesity, Morbid, Treatment Outcome, Bariatric Surgery

Disciplines

Internal Medicine | Medicine and Health Sciences | Surgical Procedures, Operative | Therapeutics

Abstract

The latest bariatric endoscopic techniques include transoral outlet reduction (TOR) and bariatric endoscopic gastric remodeling (BEGR). Weight loss and comorbidity resolution outcomes from bariatric endoscopy remain inferior to those of bariatric surgery. Additionally, some patients are either ineligible for or prefer not to undergo surgery. These factors have driven the development of adjunctive tools to enhance weight loss following bariatric endoscopy. Current tools include pharmacotherapy and technical modifications. This study reviews the effectiveness of such tools in enhancing weight loss after bariatric endoscopy. A systematic review and meta-analysis were conducted comparing BEGR with and without pharmacotherapy and TOR with and without a technical modification. The findings suggest that these adjunctive tools may improve weight loss outcomes, but given study limitations, definitive conclusions cannot be drawn.

Publisher or Conference

Obesity Surgery

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