Pancreatic Adenocarcinoma Associated With a Germline RAD51C Mutation

Division

North Florida

Hospital

Osceola Regional Medical Center

Document Type

Case Report

Publication Date

4-28-2026

Keywords

RAD51C mutation, genetic testing, hereditary cancer syndrome, homologous recombination deficiency, pancreatic adenocarcinoma

Disciplines

Digestive System Diseases | Gastroenterology | Internal Medicine | Medicine and Health Sciences | Neoplasms | Skin and Connective Tissue Diseases

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related mortality in the United States, with a 5-year survival of ∼10%-13%. Although 5%-10% of PDAC cases arise from pathogenic germline variants in cancer-predisposition genes, association with

Publisher or Conference

ACG Case Reports Journal

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