Low-grade Adenosquamous Carcinoma of the Breast in a Pregnant Patient: Case Report and Literature Review

Authors

David Bassa, HCA HealthcareFollow
Makenzie Morrissey, HCA HealthcareFollow
Adewuni Ojo
Adeel Raza

Files

Division

North Texas

Hospital

Medical City Arlington

Specialty

General Surgery

Document Type

Poster

Publication Date

4-28-2023

Keywords

adenosquamous carcinoma, neoplasms, breast neoplasms

Disciplines

Neoplasms | Surgery

Abstract

Low-grade Adenosquamous Carcinoma of the Breast: Case Report and Literature Review Authors: David Bassa DO, MaKenzie Morrissey MD, Adewuni Ojo MD, Adeel Raza MD Abstract: Introduction: Low-grade adenosquamous carcinoma (LGASC) is a rare variant of metaplastic carcinomas of the breast. It is characterized by its clinical indolence and low-grade cytomorphology. Presentation is typically asymptomatic with indeterminate imaging characteristics with diagnosis dependent solely on histopathology findings. We herein describe a case of LGASC presenting in a young premenopausal female, an extremely rare occurrence. Case presentation: A 23-year-old woman presented to the breast clinic with a left breast ultrasound demonstrating a heterogeneous ill-defined hypoechoic area in the left upper inner quadrant. She stopped breastfeeds three years postpartum and noticed a palpable left breast mass a week later. She was otherwise asymptomatic. A left breast biopsy revealed stromal fibrosis and an ultrasound-guided excisional biopsy revealed sclerosing adenosis and fibrocystic changes. Due to the discordant clinical findings, both biopsies were sent to Weill Cornell Medicine for histopathological review. The review revealed low-grade adenosquamous carcinoma arising within the background of a complex radial sclerosing lesion. The tumor was ER low positive, PR positive, and HER2 negative. Conclusion: LGASC of the breasts remains a diagnostic and therapeutic challenge. Despite being a variant of metaplastic breast carcinomas, which present as triple negative tumors with poor prognosis, this indolent lesion has a more favorable prognosis when recognized early. Given the rarity of this cancer, there are no current guidelines for best practice management of adjuvant chemoradiation. Keywords: Low-grade adenosquamous carcinoma, metaplastic breast cancer, sclerosing lesions of the breast, indolent breast cancer

Original Publisher

HCA Healthcare Graduate Medical Education

Recommended Citation

Bassa, David; Morrissey, Makenzie; Ojo, Adewuni; and Raza, Adeel, "Low-grade Adenosquamous Carcinoma of the Breast in a Pregnant Patient: Case Report and Literature Review" (2023). North Texas GME Research Forum 2023. 11.
https://scholarlycommons.hcahealthcare.com/northtexas2023/11