An Exceedingly Rare Case of Bilateral Synchronous Germ Cell Testicular Tumors of Different Histological Types

Authors

Joseph Kim, HCA HealthcareFollow
Ray Page, HCA HealthcareFollow
Gregory Moses, HCA HealthcareFollow
Rod Carlo Columbres

Files

Division

North Texas

Hospital

Medical City Weatherford

Specialty

Internal Medicine

Document Type

Poster

Publication Date

4-28-2023

Keywords

internal medicine, testicular neoplasms, pathology

Disciplines

Internal Medicine | Male Urogenital Diseases | Neoplasms | Pathology

Abstract

It is exceedingly rare to find a case of bilateral synchronous germ cell testicular tumors of different histological types, and there have been only a handful of cases because of a lack of connections through lymphatic or vascular pathways between the testes. Here we present a unique case of a 43-year-old man who initially presented to the primary care physician for increasing right testicular swelling. He had a testicular sonogram that showed a large right testicular mass as well as a 1.7 cm left testicular mass suspicious of malignancy. Pre-surgical laboratories showed PSA 0.97, alpha-fetoprotein 1875, quantitative hCG 2508, and LDH 448. He proceeded with a right inguinal orchiectomy and the pathology revealed a 9-cm embryonal carcinoma limited to the testes. Negative lymphovascular invasion with clear margins, stage IS (pT1b N0 M0). Post-surgery, the tumor markers normalized. CT scan of the abdomen and pelvis showed postsurgical changes but no evidence of lymphadenopathy or metastatic disease. Chest x-ray showed no evidence of metastatic disease. This was subsequently followed by a left inguinal orchiectomy and the final pathology revealed a seminoma, negative margins, no invasion, stage IA (pT1a N0 M0). Because of the rarity of synchronous bilateral testicular neoplasm, treatment is unique and based on the tumor stage and managed separately with close surveillance in accordance with National Comprehensive Cancer Network guidelines.

Original Publisher

HCA Healthcare Graduate Medical Education

Recommended Citation

Kim, Joseph; Page, Ray; Moses, Gregory; and Columbres, Rod Carlo, "An Exceedingly Rare Case of Bilateral Synchronous Germ Cell Testicular Tumors of Different Histological Types" (2023). North Texas GME Research Forum 2023. 25.
https://scholarlycommons.hcahealthcare.com/northtexas2023/25