North Texas GME Research Forum 2023



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North Texas


Medical City Weatherford


Internal Medicine

Document Type


Publication Date



pre-eclampsia, pregnancy-induced hypertension


Female Urogenital Diseases and Pregnancy Complications | Internal Medicine | Obstetrics and Gynecology


Cellular oxygen consumption and lactate production rates have been measured in both placental and myometrial cells to study obstetrics-related disease states such as preeclampsia. Platelet metabolic alterations indicate systemic bioenergetic changes that can be useful as disease biomarkers. We tested the hypothesis that platelet mitochondria display functional alterations in preeclampsia. Platelets were harvested from women in the third trimester of either a healthy, non-preeclamptic or preeclamptic pregnancy, and from healthy, non-pregnant women. Using Seahorse respirometry, we analyzed platelets for oxygen consumption (OCR) and extracellular acidification (ECAR) rates, indicators of mitochondrial electron transport and glucose metabolism, respectively. There was a 37% decrease in the maximal respiratory capacity measured in platelets from healthy, non-preeclamptic compared with preeclamptic pregnancy (P

Original Publisher

HCA Healthcare Graduate Medical Education

Platelets in Preeclamptic Pregnancies Fail to Exhibit the Decrease in Mitochondrial Oxygen Consumption Rate Seen in Normal Pregnancies



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