North Texas Research Forum 2024



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North Texas


Medical City Arlington


Family Medicine

Document Type


Publication Date



angioedema, edema, trandolapril, verapamil, drug related side effects and adverse reactions


Cardiovascular Diseases | Family Medicine | Medicine and Health Sciences


Angioedema is the swelling of deeper layers of skin caused by a build-up fluid, oftentimes due to the culmination of immune system activation against allergens. There are several causes of angioedema, including animal dander, exposure to various foods, insect bites, and medications such as Angiotensin-converting enzyme (ACE) inhibitors and Angiotensin II receptor blockers (ARBs). This swelling primarily presents periorbital and periorally, however can also less-commonly affect the airway. Angioedema can be life-threatening if involving the throat and larynx given the potential of respiratory airway compromise. This case presents a patient who had been on an ACE-ARB for almost 2 decades, however when switched to the combination drug of Trandolapril/Verapamil, developed life-threatening angioedema. This highlights the rare complications of this combination drug and the need for further research in the more serious adverse reactions of dihydropyridine calcium channel blockers versus non-dihydropyridine calcium channel blockers.

Original Publisher

HCA Healthcare Graduate Medical Education

Angioedema Linked to Combination Pill Trandolapril/Verapamil



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