Survival Outcomes Following Thyroidectomy in Secondary Thyroidal Metastases

Authors

Hannan Maqsood, HCA HealthcareFollow
Tanya Odisho
Yaqeen Qudah
Umar Butt
Awni Shahait

Files

Division

North Texas

Hospital

Medical City Plano

Specialty

General Surgery

Document Type

Poster

Publication Date

2026

Keywords

thyroid metastasis, thyroidectomy

Disciplines

Endocrine System Diseases | Medicine and Health Sciences | Neoplasms | Surgery

Abstract

Background: The management plan for metastasis to the thyroid from distant primary malignancies remains unclear. Methods: This systematic review is being conducted to evaluate the outcomes for performing thyroidectomy in non thyroidal metastatic cancer. Data: Data was collected via literature search using pubmed, cochrane, web of science, and google scholar.

PICO:

• Population: Patients undergoing thyroidectomy in nonthyroidal metastatic from distal primary cancer
• Intervention: Thyroidectomy (lobar/total)
• Comparison: No comparison group
• Outcomes: Overall survival Locoregional Recurrence Mortality

Results: As per literature review, renal cell carcinoma was most common, (around 30-35%) patients, followed by lung and gastrointestinal malignancies. Surgical management was associated with improved survival duration (P < .01). Locoregional recurrence was less likely in patients treated with total versus partial thyroidectomy (4.8% vs 13%). Extent of surgical management did not have a significant effect on patient survival. The median survival from surgery to death or last follow-up was ranged 2-114 months. In the literature review cohort, the OS of patients with RCC thyroid metastasis was 213.6 months, and there was no statistically significant survival difference based on the site of metastasis. Median survival after thyroid metastasis from RCC for the literature cohort was 45.6 months, respectively.

Conclusion: Surgical intervention is associated with improved survival, but expected morbidity of untreated tumors is difficult to assess. Site of origin, time to diagnosis, and surgical approach are related to survival and recurrence rates.

Original Publisher

HCA Healthcare Graduate Medical Education

Recommended Citation

Maqsood, Hannan; Odisho, Tanya; Qudah, Yaqeen; Butt, Umar; and Shahait, Awni, "Survival Outcomes Following Thyroidectomy in Secondary Thyroidal Metastases" (2026). North Texas Research Forum 2026. 39.
https://scholarlycommons.hcahealthcare.com/northtexas2026/39